The FDA's 400mg guideline is for healthy adults only. Pick who you are, optionally add your body weight, and get your personal daily caffeine maximum, then tally your drinks against it.
The U.S. Food and Drug Administration cites 400mg a day, about four or five cups of coffee, as an amount not generally associated with dangerous, negative effects for healthy adults. It is a guideline, not a target: many people sleep and feel better well below it. Source: FDA, Spilling the Beans: How Much Caffeine Is Too Much?
The European Food Safety Authority works per kilogram instead of a flat number: single doses up to 3mg/kg and habitual daily intake up to 5.7mg/kg (the equivalent of 400mg for a 70kg adult) raise no safety concerns for healthy adults. For a 60kg adult the daily figure works out to roughly 340mg, which is why this calculator lowers the limit when you enter a lower body weight. Source: EFSA Scientific Opinion on the Safety of Caffeine (2015).
The American Academy of Pediatrics discourages caffeine for children entirely and, in its clinical report on sports and energy drinks, cites 100mg per day (about one small coffee) as the ceiling for adolescents who do consume it. The AAP also advises that children and teens avoid energy drinks completely. EFSA's per-weight guidance (3mg/kg per day) gives a similar range for typical teen body weights. Source: AAP Clinical Report, Sports Drinks and Energy Drinks for Children and Adolescents (Pediatrics, 2011).
ACOG advises less than 200mg per day during pregnancy, and the CDC notes up to 300mg per day is usually compatible with breastfeeding. If this applies to you, the dedicated pregnancy caffeine calculator tracks drinks against the 200mg guideline with sources. Sources: ACOG Committee Opinion No. 462; CDC, Maternal Diet and Breastfeeding.
Sensitivity varies enormously. Variants of the CYP1A2 gene make some people metabolize caffeine several times slower than others, and slow metabolizers feel stronger, longer-lasting effects from the same cup. People with anxiety disorders, heart arrhythmias, acid reflux, or insomnia often do better at half the adult guideline or less. The 200mg figure this calculator uses for sensitive adults is a conservative starting point, not an official guideline; your own comfortable level may be lower. If caffeine worsens your anxiety, see our guide to caffeine and anxiety.